Genome Editing

Our group uses genome editing to develop crops such as rice, potato, peanut or mustard with improved properties. To this end, we are developing new TALEN and CRISPR tools and investigating the strategy of plant pests.

BACTERIAL PLANT PATHOGENS AND THEIR WEAPONS

Two organisms fight to survive. The prokaryote aims to acquire nutrients whereas the eukaryote aims to protects the integrity of its cells.

Plants are well able to defende themselves and only specialized pathogens can colonize them. These pathogens have evolved sophisticated molecular weapons. Pseudomonas syringae and Xanthomonas bacteria use a type III secretion system (T3SS) to inject ca. 30 different effector proteins into plant cells (Fig. 1). These effectors sabotage the host cell from within (Fig. 2) and we study their molecular activities.

TALEs (transcription activator-like effectors) from rice-pathogenic Xanthomonas oryzae induce plant SWEET sugar exporters. X. oryzae strains can harbour up to 26 different TALEs and we explore which plant genes are targeted.

Plant cells under attack. (1) Bacterial effector proteins (blue ball) are injected via a type III secretion system (red) into plant cells.
(2) Inside the cell, effectors interact with host components and travel to subcellular locations.
(3) TALEs from Xanthomonas bind to promoters inside the plant nucleus and induce expression of plant genes.

HEAD

Prof. Dr. rer. nat. Jens Boch
Management
Address
Herrenhäuser Straße 2
30419 Hannover
Building
Room
Prof. Dr. rer. nat. Jens Boch
Management
Address
Herrenhäuser Straße 2
30419 Hannover
Building
Room